Impact of chromosomal rearrangement upon DNA methylation patterns in leukemia

Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia

Genomic instability, including genetic mutations and chromosomal rearrangements, can lead to cancer development. Aberrant DNA methylation occurs commonly in cancer cells. The aim of this study is to determine the effects of a specific chromosomal lesion the BCR-ABL translocation t(9:22), in establishing DNA methylation profiles in cancer. Materials and methods We compared DNA methylation of 1,5...

DNA Methylation and Its Role in the Development of Leukemia

Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...

DNA methylation patterns at relapse in adult acute lymphocytic leukemia.

PURPOSE Aberrant DNA methylation of promoter-associated CpG islands is an epigenetic DNA modification observed in acute leukemias that in certain cases has been associated with a poor prognosis and increased relapse rates. To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial p...

DNA methylation patterns in

The frequency of cytosine raethylatlon at specific sites in the somatic 5S DNA (Xls) and trace oocyte 5S DNA (Xlt) of X. laevis has been determined using restriction enzymes that are inhibited by the presence of 5-methylcytosine (S^) within their cleavage sequences. 5S DNA methylation patterns were determined in genomic DNA from mature red blood cells, which express neither type of 5S gene, and...

DNA Methylation in Acute Leukemia